Research Article
Open Access
In-Patient Study of Thrombocytopenia Event Induced by Ceftriaxone, Ranitidine and Ketorolac
Siti Saidah Muthmainah*, Elin Yulinah Sukandar and I Ketut Adnyana
1- Pharmacology and Clinical Pharmacy Division, School of Pharmacy, Institut Teknologi Bandung,
Jalan Ganesa 10, Bandung 40132, Indonesia
Siti Saidah Muthmainah, Elin Yulinah Sukandar and I Ketut Adnyana: In-Patient Study of Thrombocytopenia Event Induced by Ceftriaxone, Ranitidine and Ketorolac. Asian Journal of Pharmacology and Toxicology 05 (18); 2017; 12-15.
Abstract
Introduction: Drug-induced thrombocytopenia often occurs during the patient hospitalized. Through the pharmacoepidemiology study, it can be seen thrombocytopenia induced by the use of ceftriaxone, ranitidine and ketorolac.
Objective: To assess thrombocytopenia induced by the use of ceftriaxone, ranitidine and ketorolac.
Methods: The assessment was done by identifying patients medical records were obtained retrospectively and concurrent. Furthermore, analysis of the data was assessed by case control study.
Results: In-patients using ceftriaxone, ranitidine and ketorolac risk of decreased platelets to the potential onset of thrombocytopenia. From data taken retrospectively obtained results of the odds ratio was 1.8. While the data taken concurrently, obtained odds ratio greater than 2.8.
Conclusion: Through pharmacoepidemiology studies with odds ratio analysis approach is known that the use of a ceftriaxone, ranitidine and ketorolac increasese the risk of decreased platelets potentially toward thrombocytopenia
Keywords
drug induced thrombocytopenia, ceftriaxone, ranitidine, ketorolac, pharmacoepidemiology, odds ratio
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