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Background: Trigonella foenum graecum Linn. (Commonly known as Methi or Fenugreek) seed extract belonging to family Leguminosae have been documented to elicit hypoglycemic activity. Herbal preparations of T. foenum graecum have been considered as safe, effective and economical for various ailments in Indian traditional system of medicine. Its seed extract is used for the treatment of diabetes. The present study was undertaken to evaluate the hypoglycemic potential and effect on various biochemical parameters of hydro-alcoholic extract (70% v/v) of seeds of T. foenum graecum (TGE) in

alloxan induced diabetic rats.

Materials and method: Albino Wister male rats of weighing between 150 to 200 gms of were used for the study. Diabetes was induced by injecting alloxan (120 mg/kg, i.p.). Rats were divided in different groups for the study. Group I  served as normal control, Group II served as diabetic control, Group III served as standard control and treated by Tolbutamide 100 mg/kg p.o. Group IV served as diabetic rats treated with hydro-alcoholic extract of T. foenum graecum seeds at a dosage of 1000 mg/kg body weight. All the treatments were given for 21 days. At the end of study, overnight fasted rats were sacrificed and

blood was collected to determine fasting blood glucose and biochemical

findings.

Result: Diabetic rats treated with TGE at a dose of 1000 mg/kg significantly (P<0.01) reduced fasting blood glucose and normalize the lipid profile, renal profile and hepatic profile. Improvement in the histopathology of pancreas & liver of TGE treated rats confirmed its protective role in alloxan induced diabetes.

Conclusion: It can be concluded that hydro-alcoholic extract (70% v/v) of seeds of T. foenum graecum possess antidiabetic activity and may be beneficial in improving complications associated with diabetes mellitus.