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Liver is the largest organ of the body, it plays vital role in regulation of body functions. Various herbal medicines were used traditionally for liver disorders. In this study we evaluated hepatoprotective activity and antihepatotoxic activity of ethanolic extract of Evolvulus alsinoides Linn(EAEE) was aganist CCl4 induced hepatotoxicity model in albino Wistar rats (150 – 200 gms) at a dose of 75 & 150 mg/kg b.w p.o. It was reported that Evolvulus alsinoides was used in the treatment of hypertension, memory enhancer, stomachic, nervous disorders etc. Preliminary phytochemical studies of the EAEE showed the presence of Carbohydrates, Flavonoids, Glycoside, Alkaloids and Proteins. There was no mortality when conducting the acute toxicity studies, upto a dose of 1500 mg/kg b.w p.o. Hence two test doses of 75 and 150 mg/kg b.w p.o were selected in the study. Hepatotoxicity was induced with CCl4, silymarin 50 mg/kg b.w.p.o. was used as standard. Administration of CCl4, significantly elevated the levels of SGPT, SGOT, ALP, TB, CHOL and lowered the levels of TP and ALB. When EAEE 150 mg/kg produced significant inhibition of hepatic damage by significantly (P<0.01) reversing the effects of CCl4 induced hepatotoxicity. Histopatholigical studies revealed that 90% Ethanolic extract exhibited normalization of liver architecture, as compared to silymarin. Results of our study suggest that Ethanolic extract of Evolvulus alsinoides may possess hepatoprotective activity which may be due to the presence of flavonoids in the extract.