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The present study was aimed to find out acute toxicity and investigate the analgesic and anti-inflammatory effect of the methanolic extract of Actiniopteris dichotoma bedd in rats. The acute toxicity study showed that animals fed by oral gavages tolerated the limit dose of 5000 mg/kg body weight of methanolic extract of Actiniopteris dichotoma bedd. There were no visible signs of acute toxicity during the 14 days of observation. Actiniopteris dichotoma bedd was evaluated carrageenan induced paw edema and histamine induced paw edema (250mg/kg and 500 mg/kg). At the 250 mg/kg dose of methanolic extract of Actinopteris dichotoma showed inhibition ( P < 0.05) and the maximum inhibition of methanolic extract at 500 mg/kg at the time of 180 min and 240 min (P < 0.01). Methanolic extract of Actiniopteris dichotoma bedd (250mg/kg and 500 mg/kg ) for its analgesic activity by hot plate method and tail immersion method. It showed Significant value from control P < 0.05*, P < 0.01**, P < 0.001***.