Review Article
Open Access
Endophytic microbes: A novel source for biologically/pharmacologically active secondary metabolites
S T Shukla1*, P V Habbu2, V H Kulkarni2, K S Jagadish3, Aprajita R Pandey4, V N Sutariya1
1* Shree Dhanvantary Pharmaceutical Analysis & Research Centre,Kim, Surat-394110, India. 2 Soniya Education Trust’s College of Pharmacy,Dharwad-580 002, India. 3 Department of Agricultural Microbiology, University of Agricultural Sciences, Dharwad-580005, India. 4 Percos India Private Limited New Delhi – 110092, India.
S T Shukla, P V Habbu, V H Kulkarni, K S Jagadish, Aprajita R Pandey, V N Sutariya. Endophytic microbes: A novel source for biologically/pharmacologically active secondary metabolites. Asian Journal of Pharmacology and Toxicology 02 (03); 2014; 01-16.
Abstract
Endophytes, microorganisms that reside internal tissues of all plant species, are a proven source of novel organic natural molecules, presumed to emphasizing the frontiers of drug discovery. Next to the clinically acknowledged antineoplastic agent, taxol, endophyte research has yielded potential drug, given compounds with antimicrobial, antioxidant, antiviral, antidiabetic, anti-alzheimer's disease and immunosuppressant etc. These evidences arises a hope to combat incurable diseases, drug resistance, other challenges related to human health. The potential of finding new drugs that may be effective candidates for treating newly developing diseases in humans is great. This paper focuses particularly need for new useful compounds from endophytes, the recent role of new disease, recent scenario of screening approach for novel drug and their pharmacological interest. It also describes these compounds by different functions, including some examples that illustrate the potential for human use.
Keywords
Endophytes, Secondary metabolites, Pharmacology, New drugs, Fungi, Bacetria.
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