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Aim of the study was to study effects of repeated dose administration of extract of roots of Spermadictyonsuaveolens in streptozotocin induced diabetic rats.Effects of extract of Spermadictyonsuaveolens wasstudied in streptozotocin-induced diabetic rats. 1 week after the administration of streptozotocin, diabetic rats received herbal extract orally at dose 500 mg/kg body weight for 28 consecutive days.Administration of streptozotocin resulted in 3-4 fold increase in fasting plasma glucose level. Treatment with herbal extract showed glucose lowering effect from first week. Results show that extract of roots of Spermadictyonsuaveolens possesses antidiabetic activity.