Article Details

This study was performed to investigate the anxiolytic effects of alcoholic extract of Matricaria chamomilla L (AEMC) in mice using the elevated plus-maze model (EPM), light dark model and hole board test. The extract administered orally in three different doses of 250mg/kg, 500mg/kg and 750mg/kg, were able to increase the time spent and the number of arm entries in the open arms of the elevated plus-maze, also increases the time spent by mice in the illuminated side of the light–dark test, dose of 500mg/kg and 750mg/kg showed more significant increase in nose poking and decrease locomotion in hole board test, in comparison with control animals. This effect was comparable to that of the diazepam (1.0mg/kg p.o.). These results indicate that AEMC is an effective anxiolytic agent.