The current study was carried out to investigate protective role of Alove Vera against aluminum induced changes in the body weight reduction of albino rats due to its deleterious effects. Aloe vera is a medicinal plant belonging to the family —Liliaceae, which has a wide range of therapeutic applications such as wound healing, diabetes, burns, for easing intestinal, curing ulcers and arthritic swellings. 30 adult rats were taken and divided into 3 groups 10 (5+5) for each. Animals were fed with normal diet and water ad-libitum, as Group I or control group. Group II animals were fed with normal diet and received aluminium in a dose of 98 mg/kg of body weight orally for 30 and 60 days. Group III were fed with normal diet and received aloin (100mg/kg body weight) and aluminium sulphate (98 mg/kg body weight) for 15, 30 and 60 days. On the last day of the experiment, animals were weighed on 15, 30th and 60th days respectively. The results of the present study clearly indicated that aluminium sulphate per se treated group has significantly reduced the body weight of albino rats. But after co treatment of rats with aloin the extract of Aloe vera and aluminum sulphate, the restoration of body weight was observed in co treatment group, indicating the protective role of aloin against aluminium sulphate toxicity.