The aim of this research was to determine the antioxidant and antimutagenic properties of aqueous plant extracts of Viscum album. Most of the diseases in the world today have been associated with the influence of reactive oxygen species (ROS) and mutagenic materials. Oxygen free radical induces damage due to peroxidation to biomembranes and also to DNA, which lead to tissue damage, thus resulting in the development of degenerative diseases. Antioxidant is, any substance that, when present at low concentration significantly delays or prevent oxidation of cell content like proteins, lipids, carbohydrates and DNA. Thus antioxidants neutralize the effect of free radicals through different ways and may prevent the body from various diseases. Evidence suggests that Compounds especially from natural sources such as medicinal plants are capable of providing protection against free radicals and mutagens. From the research findings, it could be deduced that Viscum album increased the antioxidant enzyme actions and also showed antimutagenic properties. This suggest that the plant can be used as therapeutic agent against a number of diseases