R. Vijay Kumar

ABSTRACT

Liver is one of the vital organs in the human body. It plays a major role in several metabolic reactions. Cirrhosis, hepatitis, jaundice, liver cancer are some of the disorders due to which the liver diminishes. The available drugs are not completely curbing the disorders and mostly they are fetching side effects. Medicinal plants can combat to these problems and can be used for the therapy. The plant Streblus asper is collected from the village area of Kesamudram, Warangal district. The plant leaves were dried, powdered and used for the extraction. Methanol and aqueous were used as solvents to prepare the extract through maceration technique. The albino rats were divided into the following groups for studying the hepatoprotective activity. Group- I control, group-11- CCL (lml /kg 1:l in coconut oil- i.p.,), group- I11 - CCl4+ Liv - 52 (5ml/kg), group-IV - CCl4+ SAALE (Streblus asper Aqueous Leaf Extract) 200mg/kg, , group-V- CCl4+ SAALE 400mg/kg, group-VI- CCL+ SAMLE-(Streblus asper Methanol Leaf Extract) 200 mg/kg and group- VII- CCl4+ SAMLE 400 mglkg. 8 rats were maintained in each group, the treatment of the extract and liver tonic was done through oral with gastric gavage for 14 days. On 15th day the blood of the rats was collected through retro orbital plexus.