Aurel Constant ALLABI

ABSTRACT

Introduction: TR-Y017 is a phytomedicine widely used in Benin and which has been claimed effective against anemia, hepatitis, allergies, urinary infections and cancer by the manufacturer. In order to establish the safety use of TR-Y017, this study aims to evaluate the effects of its acute and sub-acute oral administration to Wistar albino rats. Methods: Acute oral toxicity tests were performed on Wistar rats by oral force feeding with a single dose of 2000 mg/kg in accordance with the Organization for Economic Co-operation and Development (OECD) Guidelines and animals were observed for 14 days to record various clinical signs or death. In sub-acute toxicity study, female rats were divided into 4 groups of 5 animals each. Three doses 12.5; 25 and 37.5 mg/kg body weight for 28 days were received by groups 2 to 4. Physiological behavior and body weight were evaluated. Biochemical, haematological and histological Analysis were realized at the end of each study.