Dr. K.L.Krishna

ABSTRACT

The present study was aimed to assess the memory impairment activity of Carbamazepine (CBZ) in presence and absence of Nardostachys jatamansi. Memory impairments are common side effects in epileptic patients and antiepileptic drugs can worsen memory impairment. Nootropic drugs may be of potential in reducing the memory impairment when given along with antiepileptic drugs. Therefore ethanolic extract of Nardostachys jatamansi (ENJ) was prepared and standardized by preliminary phytochemical tests, determination and total phenolic and flavonoid content and in-vitro antioxidant activities like DPPH, Super oxide (SO), Hydroxyl (OH), Nitric oxide (NO) and Hydrogen peroxide (H2O2) scavenging activity. CBZ was administered orally for 29 days in rats to assess the memory impairment ability by employing Barne’s maze on PTZ induced convulsions.