Sowjanya

ABSTRACT

Cognitive enhancing activity of ACV on scopolamine induced memory impairment in mice was investigated by using elevated plus maze and estimation of biochemical parameter in terms of AChE activity. Two doses (0.51ml/kg) and (1.02 ml/kg b.wp.o) of ACV were subjected for the evaluation of nootropic activity against the amnesia induced by scopalamine (0.4mg/kg, i.p) in young mice. Pirecetam (400 mg/kg i.p) was served as standard in both the models. The animals were challenged for twice examination in 27 days study. The long term administration of both the lower (0.51ml/kg) and higher dose (1.02ml/kg) of ACV produced significant reduction of TL (P<0.01) and (P<0.05) in EPM model on both 19th and 27th day when compared with control and induced groups. ACV at higher dose significantly (p<0.01) reduce the activity of AchE in the brain indicates the improvement in learning and retention of memory in young mice, concluded that apple cider vinegar was found to be effective against amnesia induced by scopalamine.