Vivek P. Kahale

ABSTRACT

he core finding of the present preclinical study is to develop and standardize the animal model of diabetic foot ulcers by using varying doses of Alloxan by using excision and incision wound ulcer technique. Optimization with subcutaneous administration of the chemical inducer (Alloxan) through blood glucose and body weight monitoring of rat. Administration of prescribed oral and topical doses of Aloe Vera is remarkably protective effects in diabetic and its complication using male wistar rats against alloxan induced Diabetic Foot Ulcers (DFU). Diabetes mellitus is an endocrine disorder. Diabetes mellitus is now defined as a metabolic disorder in which the body’s capacity to utilize glucose, fat and protein is disturbed due to insulin deficiency, insulin resistance or both. Diabetes is a condition which is known to be associated with a variety of connective tissue abnormalities. The collagen content of the skin is decreased as a result of reduced biosynthesis and or accelerated degradation of newly synthesized collagen and epithelisation.