C. Tsompos

ABSTRACT

Aim: The aim of this experimental study was to examine the effect of U- 74389G on rat model and particularly in a hypoxia - reoxygenation (HR) protocol. The effect of that molecule was studied hematologically using blood mean white blood cells levels. Materials and methods: 40 rats of mean weight 231.875 g were used in the study. White blood cells levels were measured at 60 min (groups A and C) and at 120 min (groups B and D) of reoxygenation. U-74389G was administered only in groups C and D. Results: Results were that U-74389G administration kept significantly increased the white blood cells level by 30.12%+10.87% (p=0.0050). Reoxygenation time also kept significantly increased the white blood cells level by 25.18%+11.64% (p=0.0300). However, U-74389G administration and reoxygenation time together kept significantly increased the white blood cells level by 23.64%+6.32% (p=0.0003).