Sandeep Kaur

ABSTRACT

Cadmium is an extremely hazardous heavy metal, which is widely distributed throughout the biosphere due to increase in industrialization. Its accumulation in blood affects various organs and causes many clinical dysfunctions. The main purpose of this study was to evaluate the toxic effects of different doses of cadmium (Cd) on liver function through biochemical analysis. For this, animals were divided into three groups. Group 1: Control group. Group 2: received a single dose (acute dose) of 2mg/kg body weight of CdCl2 intraperitoneally where autopsies were done on 1, 7, 15 and 30 days post treatment. Group 3: received 0.01mg/kg body weight/day (chronic dose) of CdCl2 intraperitoneally daily for 15 and 30 days. It was observed that Cd led to significant increase in the level of serum cholesterol, LDL-c, VLDL-c and triglycerides on 15 and 30 days post treatment in both acute and chronic dose treated mice as compared to control. Similarly, in the case of transaminases, activity of SGPT was found to be increased significantly (P<0.05) in cadmium treated groups (2 and 3) compared to control mice but SGOT was increased significantly (P<0.01) only in chronic dose treated mice. Hence, the present study shows that chronic doses of cadmium to mice showed more deleterious results.