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ABSTRACT
Design and pharmacokinetics of a new formulation of modified release of clindamycin orally for dogs
Elizabeth Ortega Molina
ABSTRACT
Clindamycin is an antibiotic by choose, because of its wade distribution into organs and tissues, it is used in the treatment of osteomyelitis, however the owners of dogs does not have the discipline necessary to complete the treatment, affecting therapeutic response. The innovation of polymeric matrix of hydroxypropylmethylcellulose (HPMC) + poloxamer 188 and/or made of made HPMC + carbopol with the addition of clindamycin will result in modified release formulations, increasing therapeutic concentration time in serum, and decreasing dosing frequency
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