T. K. Sar

ABSTRACT

The pharmacokinetics of ceftriaxone, sulbactam individually and in combination (ceftriaxone: sulbactam, 1:1) at 20 mg kg-1 body weight (bw) as single dose intravenous administration (i.v.) was conducted in healthy and experimental Escherichia coli O157:H7 induced mastitis in black Bengal goats. Semi logarithmic plot of plasma ceftriaxone and sulbactam concentrations against time in healthy and mastitis induced goats alone and in combination witnessed 2-compartment models. Ceftriaxone could not be detected in plasma beyond 6 h in individual therapy and 8 h in combination therapy with sulbactam. Ceftriaxone persisted in the milk for longer time in experimental mastitis when given in combination with sulbactam.